Endocrine Abstracts

IntroductionThe prevalence of childhood obesity continues to increase nowadays but also its long-term complications, particularly metabolic and cardiovascular, and this is due in large part to all the current modern conditions and means that promote sedentary lifestyle and lack of ’physical activityMaterial and methodsWe developed a 16-week aerobic exercise program (four 60-minute sessions per week at 70...

IntroductionEmpty sella syndrome (ESS) is a rare condition in which the sella turcica is partially or completely filled with cerebrospinal fluid. ESS can be classified as primary or secondary, depending on the identification of underlying etiologies. Whether empty sella has any functional implications in causing pituitary hormonal disturbances needs to be understood. The aim of our study was to assess the incidence of pituitary hormonal disturbances in p...

IntroductionNon alcoholic steato-hepatitis (NASH) is the most common chronic liver disease in developed countries rare in type 1 diabetes it is associated with an increased risk of complications in patients with type 1 diabetes mellitus (T1DM). The aim of this study is to clarify the characteristics of NASH in patients with T1DM.Materials and methodswe conducted a retrospective descriptive study in non-alcoho...

32 year old female with no prior past medical problems presented to hospital with a two week history of rapid onset delusional psychosis with religious themes, paranoid ideas and rapidly developing into catatonia. There was no previous history of psychiatric disorders. On physical examination the Glasgow Coma Score (GCS) was 15 and she was responding to visual hallucinations; speaking to imaginary person and reported seeing objects. She was afebrile and bedside observations we...

Case history: A 24-year-old previously healthy male presented to his GP with unilateral “gynaecomastia”, prompting investigations which showed a low FSH of 0.7 (1–12 IU/l). He had normal libido, erectile function, and a normal sense of smell. He had no children. He was subsequently investigated for persistent dysuria but imaging and cystoscopy were entirely normal. He was a non-smoker who took little alcohol and worked as an insurance agent. His past medical his...

Case history: A 53-year-old obsessive body builder, presented with severe constipation. He had used growth hormone, anabolic steroids and testosterone at variable doses for over 20 years. He had a protein intake of over 400 g/day over an extended period. He denied osmotic symptoms, joint or muscle pains, and excessive tiredness. Previously, he had benign prostatic hyperplasia and renal stone disease but was not on any prescription medication and took no over the counter ‘...

Background: Insulinoma is the most common cause of hypoglycaemia due to endogenous hyperinsulinemia. However, they can sometimes present with atypical features. Some of the patients can also develop serious adverse effects to medical treatment. We present a case with atypical features and further developed serious adverse effects with medical treatment for insulinoma.Case presentation: A 42-year-old Caucasian female presented with recurr...

Introduction: Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterised by refractoriness of target tissue to thyroid hormone. Over 80% of cases are due to mutations in the thyroid hormone receptor beta (THR β) gene with over 100 mutations identified to date. The clinical manifestations vary from common feature as goitre to less common sinus tachycardia, learning disabilities, growth and developmental delay. Aim: We rep...

Introduction: Transition from paediatric to adult care is a challenging time for patients with long-term conditions (NICE, 2016), care should support patients to minimize further emotional, physical and social difficulties.Aims: To improve the quality of care for paediatric patients with diabetes through transition to adult care at Darent Valley Hospital (DVH). Our hypothesis is that is transitional care for diabetes at DVH meeting NICE guidelines or not...

Background: Overnight dexamethasone suppression tests (ONDST) are conducted to investigate patients with symptoms suggestive of cortisol hypersecretion or if an adrenal incidentaloma is identified. Cortisol levels of 50 nmol/l and above following ONDST may be related to autonomous cortisol secretion (ACS) and require further investigation. Determining likely presence of ACS is essential given reported associations with type 2 diabetes mellitus (T2DM), obesity, cardiovascular d...